Estrogen receptor modulator 1

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

雌激素受体调节剂 1 可使他莫昔芬耐药、激素非依赖性异种移植肿瘤消退。雌激素受体调节剂 1 是一种口服活性选择性雌激素受体调节剂 (SERM) (pIC50: 0.46)。

Estrogen receptor modulator 1 causes regression of Tamoxifen-resistant, hormone-independent xenograft tumors. Estrogen receptor modulator 1 is an orally active and selective estrogen receptor modulator (SERM) (pIC50: 0.46).

Estrogen receptor modulator 1 (compound 18) (100 nM; 10 days)inhibits T47D:A18/PKCα and T47D:A18-TAM1 colony formation.Estrogen receptor modulator 1 (100 nM; 9 days) significantly inhibits the growth of MCF-7:5C cell, and induces apoptosis in these cells 6 days. Cell Proliferation Assay Cell Line:T47D:A18/PKCα and T47D:A18-TAM1 cells Concentration:100 nM Incubation Time:10 days Result:Inhibit T47D:A18/PKCα and T47D:A18-TAM1 colony formation.Cell Viability Assay Cell Line:MCF-7:5C cells Concentration:100 nM Incubation Time:9 days Result:Significantly inhibited the growth of MCF-7:5C cells.

Estrogen receptor modulator 1 (1.5 mg/animal; p.o. ; daily for 2 weeks) results in regression of T47D:A18/PKCα tumors. Animal Model:4-6 week old athymic mice (Harlan-Sprague-Dawley) Dosage:1.5 mg/animal Administration:p.o. ; daily for 2 weeks Result:Significantly reduced tumor volume.

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Endocrinology/Hormones

Estrogen Receptor/ERR

Estrogen Receptor/ERR

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63676-22-2

242.29

C14H10O2S

>98% (HPLC)

DMSO:10 mM

OC1=CC=C(C=C(C2=CC=C(O)C=C2)S3)C3=C1

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(-20℃)

With Ice Pack

≥ 2 years